HDL, referred to as the “good” cholesterol, has the ability to clear built-up cholesterol from the arteries and Enhance in its removal from the body. LDL, the “bad” cholesterol, is linked to heart problem and is involved in the fatty build-up on artery walls known as Deposition of substances on the wall of blood vessel, Leading to narrowing blood vessel or \"hardening of the arteries\". Recent research indicates that low HDL levels are a strong predictor of cardiovascular problem.

One of Policosanol’s important actions is to reduce the abundance of cells in the arteries by inhibiting the oxidation of LDL. Oxidized LDL is dangerous. It promotes the destruction of blood vessels by creating a chronic inflammatory response. Oxidized LDL can also provoke metalloproteinase enzymes. These enzymes promote blood vessel destruction, partly by interfering with HDL’s protective effect. Healthy arteries are lined with a smooth layer of cells that permit the blood to pass with no resistance. Unhealthy arteries become overwhelmed with cells, causing the blood passage to narrow and eventually be blocked which can lead to heart attack.

In recent studies, Policosanol has been compared favorably to statin drugs, which are lipid-lowering drugs that reduce cholesterol levels by inhibiting an enzyme involved in the biosynthesis of cholesterol. Statin drugs and Policosanol show similar performance with reducing LDL levels but and only Policosanol shows better performance with increasing HDL levels. Research is showing that high levels of HDL cholesterol may be the most important factor in protecting against cholesterol-induced arterial problem.

Policosanol also appears to be Enhanceful for intermittent claudication, a problem characterized by severe occlusion of the arterial system in the lower part of the body. The arteries supplying the legs with blood may become seriously blocked in advanced stages of Deposition of substances on the wall of blood vessel, Leading to narrowing blood vessel (hardening of the arteries). This can lead to severe, crampy Discomfort when you walk more than a short distance, because the muscles are starved for oxygen. Although we don' know how Policosanol Enhances in this condition, evidence suggests that it can "thin" the blood (or technically, impair platelet aggregation) to about the same extent as aspirin at a dose of 100 mg per day.