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| Description GS-750 |
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This supplement is the same great product as our original 500-mg version but more convenient - you need only two tablets per day. Glucosamine sulfate is up to 98% absorbable, which makes it readily available to the body to support healthy articular cartilage. Clinical studies show it's a key building block for connective tissue and cartilage.
Benefits
Clinically studied to Enhance build and support joint cartilage.
Up to 98% absorbable—more readily available to support healthy cartilage.
Key Features
The same ingredients as America’s original glucosamine sulfate product.
Doctor recommended.
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| GS-750
Ingredients |
| Supplement
Facts |
Serving Size: 2 Tablets |
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| Ingredients |
Amount |
%DV |
| Calories |
10 |
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| Total Carbohydrate |
2 g |
<1% |
| Dietary Fiber |
1 g |
4% |
| Chloride (from glucosamine sulfate) |
234 mg |
7% |
| Sodium |
150 mg |
6% |
| Glucosamine Sulfate (stabilized) (shrimp shells) |
1.5 g |
* |
Other Ingredients:
cellulose, modified cellulose, magnesium stearate, soy lecithin, and carnauba wax.
sugar, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring or preservatives. This product contains natural ingredients; color variations are normal.
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This supplement is the same great product as our original 500-mg version but more convenient—you need only two tablets per day.
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How Does It
Work?:
Osteoarthritis (OA) is a slowly progressive
disease characterized by a continual breakdown of articular cartilage. The
joints most often affected by OA are the knees, hips, spine, and hands. Clinical
manifestations of OA include pain, stiffness, and decreased range of motion of
the affected joints.
Glucosamine is an
aminomonosaccharide, a product of the addition of an amino group to
glucose. It occurs naturally in the body. Glucosamine is a basic building block
for the biosynthesis of glycosaminoglycans (GAGs) and proteoglycans (PGs) (giant
molecules with many GAGs attached), which are important constituents of the
articular cartilage. It also is required for the formation of lubricants and
protective agents for the joints. Glucosamine has been reported to stimulate PGs
synthesis in articular cartilage inhibit degradation of PGs, and provide the
building blocks to maintain healthy cartilage and joints.
Glucosamine sulfate is the sulfate salt
of glucosamine. In solution or in the human body, glucosamine sulfate
dissociates into glucosamine and sulfate ions. The sulfate moiety plays an
important role in the synthesis of PGs, because the constituent GAGs are highly
sulfated. Depletion of sulfate leads to decreased synthesis of GAGs, and sulfate
administration counteracts the deleterious effect of sulfate depletion.
Glucosamine sulfate is highly hygroscopic,
which means it attracts and absorbs water very easily, by nature. The amino
group in the molecule is likely to be oxidized, which causes degradation of the
molecule, if it is not stabilized by sodium and chloride. This constitutes a
non-hygroscopic substance, which is stable at normal temperature and relative
humidity. To date, more than 20 clinical studies using glucosamine sulfate have
been reported, with nearly 3,000 patients receiving either glucosamine sulfate
or placebo. These studies show a favorable response to glucosamine sulfate vs.
placebo in supporting healthy joint function.
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Precautions:
Glucosamine sulfate has been administered safely to individuals with a
variety of conditions, including circulatory disease, liver disorders, diabetes,
lung disorders, and depression, with no observed interference with either the
course of the illness or pharmacological treatment for these conditions.
However, a small number of transient mild gastrointestinal problems have been
associated with ingestion of glucosamine sulfate. These complaints are generally
mild and are reversed when glucosamine sulfate is discontinued. Additionally,
taking the product with meals may alleviate mild gastrointestinal distress.
Recently, a concern has been expressed about the potential for glucosamine to
induce insulin resistance. The possibility of glucosamine induced insulin
resistance is a speculation based on animal studies.9 To date, no
abnormalities in glucose metabolism have been reported in individuals taking
glucosamine sulfate.
In healthy individuals, a single dose of glucosamine hydrochloride (20 grams)
was found to have little influence on blood glucose levels or the effect of
insulin on blood glucose levels. In addition, administration of 1.5 grams of
glucosamine sulfate for more than two weeks showed no significant changes of
blood glucose levels in osteoarthritis patients and osteoarthritis patients with
diabetes. Furthermore, a placebo-controlled study with glucosamine sulfate
reported a trend of decreased blood glucose levels in subjects with or without
diabetes mellitus during a 4-week period.
In a larger 3-year study, the same results were found: a trend of decreased
blood glucose levels in subjects with or without diabetes mellitus. A recent
study with fifteen non-diabetic subjects showed that administration of
glucosamine sulfate (500 mg three time daily) for 12 weeks did not change
fasting glucose levels.
Although a trend in increasing fasting insulin levels was reported in an
April 2000 study with fifteen non-diabetic subjects, the results of this study
need to be replicated and confirmed in a larger controlled trial before any
conclusion can be drawn regarding the relationship between the use of
glucosamine sulfate and insulin resistance. The National Institutes of Health (NIH)
has recently sponsored the first study in the United States to evaluate
glucosamine and chondroitin in patients with osteoarthritis.14 Until
high quality studies, such as the NIH study, are completed, it may be prudent
for individuals with diabetes or a predisposition for diabetes to work with
their licensed healthcare professional to monitor blood sugar and insulin levels
if they are taking glucosamine sulfate.
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These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, cure, mitigate, treat, or prevent any disease.
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